Chiefs-Giants betting line & prediction: Can Kansas City get right in Week 3?

The Kansas City Chiefs visit the New York Giants in Week 3, still chasing their first win of the season on “Sunday Night Football.”

Here’s everything you need to know before kickoff — and a game prediction.

How to watch Chiefs at Giants

Kickoff: 7:20 p.m. Central Time

Where: Metlife Stadium in East Rutherford, New Jersey

TV: NBC (Channel 41 in Kansas City)

Radio: KFNZ (96.5 FM in Kansas City, KNSS 98.7 FM in Wichita)

Betting line: Chiefs -5.5

Behind the matchup

For the first time since 2014, the Chiefs enter their Week 3 matchup with an 0-2 record. The Giants are 0-2 for the second straight season.

In 2025, the story for Kansas City has been one of squandered opportunities.

Even with Rashee Rice suspended and Xavier Worthy missing all but three snaps due to injury, the Chiefs were in a position to win both of their first two games on the back of the late-game efforts of quarterback Patrick Mahomes.

Trailing by a score to both the Chargers in Week 1 and Eagles in Week 2, critical mistakes by historically reliable players saw the matchups go the other way.

In Week 1, Chris Jones missed an assignment late that allowed Chargers quarterback Justin Herbert to convert a crucial first down. In Week 2, a bobbled pass by Travis Kelce led to an interception and 14-point swing, giving the Eagles control and an eventual victory.

The Giants have dropped two division games to start their season — first a dispiriting 21-6 loss to the Washington Commanders followed by a 40-37 heartbreaker to the Dallas Cowboys in overtime.

Quarterback Russell Wilson had a rough outing in Week 1 before exploding for 450 passing yards against Dallas, finishing 30-of-41 for three touchdowns and one interception.

Much like the Chiefs, the Giants have struggled getting any semblance of a run game going in the first two weeks of the season. To its credit, Kansas City has mostly bottled the run (3.6 yards per carry allowed) on defense, while New York may prove to be just what the doctor ordered (5.9 yards per carry allowed) for Isiah Pacheco and Kareem Hunt.

New York is not without its own injury issues, especially at the second level of its defense. Inside linebacker Micah McFadden went to the Reserve/Injured list after a foot injury in Week 1, and his replacement, Darius Muasau, suffered a concussion in Week 2. A third inside linebacker, Chris Board, joined McFadden on the injured list due to a chest injury in the same game.

Another six Giants starters began the practice week with a limited designation on Wednesday, including starting left tackle Andrew Thomas, who has yet to play in a game due to Lisfranc surgery. There is optimism he could make his season debut at home against Kansas City.

Wilson’s big Week 2 passing numbers may concern the Chiefs, who may be without cornerback Kristian Fulton. Fulton and defensive end Mike Danna did not practice on Wednesday. Worthy and rookie receiver Jalen Royals logged limited workouts.

Kansas City tackles Josh Simmons and Jawaan Taylor will be up for a challenge, as New York currently has three pass rushers — Abdul Carter, Brian Burns and Kayvon Thibodeaux — with at least seven pressures. Burns, who should mostly go up against Simmons, has turned his pressures into a team-leading three sacks.

Game prediction

With both teams desperate for their first win, it’s difficult to bet against Mahomes and Andy Reid.

The Chiefs aren’t without issues — injuries, run game and pass rush to name a few — but New York feels like the perfect place to bounce back and get right.

The Giants keep it too close for comfort into the third quarter, but the Chiefs find a way to come home with their first win.

Winner: Chiefs 27, Giants 18

Pick to cover: Chiefs

This story was originally published September 18, 2025 at 6:00 AM.

Pete Sweeney

The Kansas City Star

Pete Sweeney is The Star’s Kansas City Chiefs insider and beat writer. He has covered the team since 2014.