The Missouri women seemed well on their way on Wednesday night to pushing their winning streak to five games.
Instead, Saint Louis mounted a huge comeback in the fourth quarter and beat the Tigers 72-61 at Chaifetz Arena in Saint Louis.
MU had a 58-38 lead after the third quarter, but the Billikens outscored the Tigers 34-8 in the fourth quarter.
Saint Louis had never beaten Missouri in 20 previous meetings.
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Sophie Cunningham had 21 points for MU, and Cierra Porter added 16 points and nine rebounds.
Missouri fell to 10-4 on the season, while Saint Louis improved to 9-3. The Tigers open Southeastern Conference play on Jan. 1 at home against Georgia.