Danielle Lawrence scored a game-high 24 points and IUPUI routed visiting Missouri 73-45 on Sunday.
The Jaguars (6-1) used an early 16-5 run to break a 6-6 tie and never trailed again, leading 41-21 at halftime.
Sophie Cunningham scored 13 points to lead Mizzou (6-3). It was her eighth time scoring in double figures this season.
Cierra Porter added 12 points and six rebounds for the Tigers.
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Mizzou will host SIU-Edwardsville at 7 p.m. Wednesday.