A gunman crept up to a house on the 4200 block of College Avenue after 3 a.m. Friday and shot through a bedroom wall as well as another part of the house.
A man and a woman who were inside were taken to a hospital with serious injuries.
According to media reports, nine people were inside the house at the time of the shooting.
Police used a Kansas City Area Transportation Authority bus to transport four adults and three kids from the house.
Authorities do not yet have a suspect description.